Two appliances and crews from High Wycombe attended, along with an officer.
One car had overturned onto its roof when they arrived.
The firefighters released one man, injured, and provided immediate emergency care, before passing him into the care of South Central Ambulance Service. Sadly, the man was pronounced dead at the scene.
The firefighters made the scene safe and left the incident in the hands of Thames Valley Police.
An appeal for witnesses to the collision has been issued.