One appliance and crew from Broughton attended.
The collision had occurred on the H4, Dansteed Way, at the Fennel Drive junction.
Two men and one woman were out of their vehicles, injured, before they arrived. The firefighters provided immediate emergency care and oxygen therapy, before them into the care of South Central Ambulance Service.
The H4, Dansteed Way was closed in both directions while they worked at the scene.
They used an environmental pack to absorb spilt engine oil.
The incident was left in the hands of Thames Valley Police.