Two appliances and crews from West Ashland and one from Broughton attended, along with an officer.
The firefighters provided immediate emergency care to those involved.
Sadly, one woman died at the scene.
They released two further women, injured, and passed them into the care of the ambulance service.
The firefighters used two immediate emergency care packs.
Thames Valley Police also attended.
The road was closed while the emergency services worked at the scene.
Thames Valley Police has issued an appeal for witnesses.