One appliance and crew from Broughton and one from West Ashland attended, along with an officer.
The firefighters provided immediate emergency care to one man, injured, before passing him into the care of South Central Ambulance Service.
One woman and one boy, both injured, were cared for by South Central Ambulance Service.
The firefighters used one thermal imaging camera and one hose reel jet and made the scene safe. One lane of the road was closed while they worked at the scene.
The incident was left in the hands of Thames Valley Police.
