Two appliances and crews from West Ashland attended.
The firefighters assisted South Central Ambulance Service. They provided immediate emergency care to one woman who was out of her car, injured, when they arrived. South Central Ambulance Service cared for a second woman who was also out of her car, injured, when they arrived.
Two men and a third woman were out of their cars, uninjured, before they arrived.
The road was closed while they worked at the scene.
The firefighters also helped move the cars from the road.
The incident was left in the hands of Thames Valley Police.