Two appliances and crews from High Wycombe attended, along with an officer.
One car was on its roof when they arrived.
One woman was released, injured, before they arrived. The firefighters provided her with immediate emergency care and passed her into the care of South Central Ambulance Service.
The firefighters used hydraulic cutting gear to release one man, injured, who was also passed into the care of the ambulance service.
The firefighters made the scene safe.