Two appliances and crews from High Wycombe, one from Thame, along with an officer attended.
The firefighters used one set of breathing apparatus, one hose reel, a thermal imaging camera, an immediate emergency care kit and an environmental grab pack.
A man and woman were passed into the care of South Central Ambulance Service.
A road closure was put in place on the hard shoulder and lane one.
The incident was left in the hands of Thames Valley Police.
