Two appliances and crews from High Wycombe, one from Slade Park, Oxford, one from Thame and a water carrier from Wheatley attended, along with two officers.
A derelict two-storey building was fully involved in fire when they arrived. The incident generated multiple calls to Thames Valley Fire Control Service.
The firefighters used two hose reel jets and a thermal imaging camera.
The electricity provider also attended and isolated the electricity supply to the building.
Thames Valley Police was notified, and a scene cordon established around unsafe areas of the building.